First Round | Pick | Team | Player | Position | College |
| 1 | Houston | Jadeveon Clowney | Defensive End | South Carolina |
| 2 | St. Louis | Jake Matthews | Offensive Tackle | Texas A&M |
| 3 | Jacksonville | Teddy Bridgewater | Quarterback | Louisville |
| 4 | Cleveland | Derek Carr | Quarterback | Fresno State |
| 5 | Oakland | Sammy Watkins | Wide Receiver | Clemson |
| 6 | Atlanta | Khalil Mack | Linebacker | Buffalo |
| 7 | Tampa Bay | Ra'Shede Hageman | Defensive Tackle | Minnesota |
| 8 | Minnesota | Blake Bortles | Quarterback | Central Florida |
| 9 | Buffalo | Eric Ebron | Tight End | North Carolina |
| 10 | Detroit | Mike Evans | Wide Receiver | Texas A&M |
| 11 | Tennessee | Darqueze Dennard | Cornerback | Michigan State |
| 12 | New York (G) | Greg Robinson | Offensive Tackle | Auburn |
| 13 | St. Louis | David Yankey | Guard | Stanford |
| 14 | Chicago | Aaron Donald | Defensive Tackle | Pittsburgh |
| 15 | Pittsburgh | Zack Martin | Offensive Tackle | Notre Dame |
| 16 | Dallas | Ha'Sean Clinton-Dix | Safety | Alabama |
| 17 | Baltimore | Marqise Lee | Wide Receiver | USC |
| 18 | New York (J) | Kelvin Benjamin | Wide Receiver | Florida State |
| 19 | Miami | Cyril Richardson | Offensive Line | Baylor |
| 20 | Arizona | Jace Amaro | Tight End | Texas Tech |
| 21 | Green Bay | Calvin Pryor | Safety | Louisville |
| 22 | Philadelphia | Justin Gilbert | Cornerback | Oklahoma State |
| 23 | Kansas City | Jordan Matthews | Wide Receiver | Vanderbilt |
| 24 | Cincinnati | Lamarcus Joyner | Defensive Back | Florida State |
| 25 | San Diego | Anthony Barr | Linebacker | UCLA |
| 26 | Cleveland | Jason Verrett | Cornerback | Texas Christian |
| 27 | New Orleans | Bishop Sankey | Running Back | Washington |
| 28 | Carolina | Allen Robinson | Wide Receiver | Penn State |
| 29 | New England | Louis Nix | Defensive Tackle | Notre Dame |
| 30 | San Francisco | Davante Adams | Wide Receiver | Fresno State |
| 31 | Denver | Travis Swanson | Center | Arkansas |
| 32 | Seattle | Will Sutton | Defensive Tackle | Arizona State |
Second Round | Pick | Team | Player | Position | College |
| 33 | Houston | Johnny Manziel | Quarterback | Texas A&M |
| 34 | Washington | Kyle Fuller | Cornerback | Virginia Tech |
| 35 | Cleveland | Brandin Cooks | Wide Receiver | Oregon State |
| 36 | Oakland | Tre Mason | Running Back | Auburn |
| 37 | Atlanta | Troy Niklas | Tight End | Notre Dame |
| 38 | Tampa Bay | Xavier Su'a-Filo | Guard | UCLA |
| 39 | Jacksonville | Kony Ealy | Defensive End | Missouri |
| 40 | Minnesota | Bradley Roby | Cornerback | Ohio State |
| 41 | Buffalo | Ryan Shazier | Linebacker | Ohio State |
| 42 | Tennessee | Charles Sims | Running Back | West Virginia |
| 43 | New York (G) | Timmy Jernigan | Defensive Tackle | Florida State |
| 44 | St. Louis | David Fales | Quarterback | San Jose State |
| 45 | Detroit | Cyrus Kouandjio | Offensive Tackle | Alabama |
| 46 | Pittsburgh | Kyle Van Noy | Linebacker | BYU |
| 47 | Dallas | Gabe Jackson | Guard | Mississippi State |
| 48 | Baltimore | Antonio Richardson | Offensive Tackle | Tennessee |
| 49 | New York (J) | Austin Seferian-Jenkins | Tight End | Washington |
| 50 | Miami | Morgan Moses | Offensive Tackle | West Virginia |
| 51 | Chicago | Ed Reynolds | Safety | Stanford |
| 52 | Arizona | Zach Mettenberger | Quarterback | LSU |
| 53 | Green Bay | Jeremiah Attaochu | Linebacker | Georgia Tech |
| 54 | Philadelphia | Odell Beckham Jr. | Wide Receiver | LSU |
| 55 | Cincinnati | Shayne Skov | Linebacker | Stanford |
| 56 | San Francsico | Deone Bucannon | Safety | Washington State |
| 57 | San Diego | Trent Murphy | Defensive End | Stanford |
| 58 | New Orleans | Dee Ford | Defensive End | Auburn |
| 59 | Indianapolis | Chris Smith | Defensive End | Arkansas |
| 60 | Carolina | Pierre Desir | Cornerback | Lindenwood |
| 61 | San Francisco | Stanley Jean-Baptiste | Cornerback | Nebraska |
| 62 | New England | C.J. Fiedorowicz | Tight End | Iowa |
| 63 | Denver | Stephon Tuitt | Defensive Line | Notre Dame |
| 64 | Seattle | Jarvis Landry | Wide Receiver | LSU |
Third Round | Pick | Team | Player | Position | College |
| 65 | Houston | Ka'Deem Carey | Running Back | Arizona |
| 66 | Washington | Jimmy Ward | Safety | Northern Illinois |
| 67 | Oakland | Tajh Boyd | Quarterback | Clemson |
| 68 | Atlanta | Trevor Reilly | Defensive End | Oregon |
| 69 | New York (J) | Loucheiz Purifoy | Cornerback | Florida |
| 70 | Jacksonville | Lache Seastrunk | Running Back | Baylor |
| 71 | Cleveland | Ego Ferguson | Defensive Tackle | LSU |
| 72 | Minnesota | Paul Richardson | Wide Receiver | Colorado |
| 73 | Buffalo | Anthony Steen | Guard | Alabama |
| 74 | New York (G) | Brandon Coleman | Wide Receiver | Rutgers |
| 75 | St. Louis | Yawin Smallwood | Linebacker | UCONN |
| 76 | Detroit | Chris Borland | Linebacker | Wisconsin |
| 77 | San Francisco | Dominique Easley | Defensive Line | Florida |
| 78 | Dallas | Jimmy Garoppolo | Quarterback | Eastern Illinois |
| 79 | Baltimore | Carlos Hyde | Running Back | Ohio State |
| 80 | New York (J) | Ahmad Dixon | Safety | Baylor |
| 81 | Miami | E.J. Gaines | Cornerback | Missouri |
| 82 | Chicago | DaQuan Jones | Defensive Tackle | Penn State |
| 83 | Cleveland | Marion Grice | Running Back | Arizona |
| 84 | Arizona | Ed Stinson | Defensive End | Alabama |
| 85 | Green Bay | Daniel McCullers | Defensive Tackle | Tennessee |
| 86 | Philadelphia | Terrence Brooks | Safety | Florida State |
| 87 | Kansas City | Colt Lyerla | Tight End | Oregon |
| 88 | Cincinnati | Aaron Murray | Quarterback | Georgia |
| 89 | San Diego | Jared Abbrederis | Wide Receiver | Wisconsin |
| 90 | Indianapolis | Jackson Jeffcoat | Linebacker | Texas |
| 91 | New Orleans | Seantrel Henderson | Offensive Tackle | Miami (F) |
| 92 | Carolina | Ty Zimmerman | Safety | Kansas State |
| 93 | New England | Josh Huff | Wide Receiver | Oregon |
| 94 | San Francisco | Bryan Stork | Center | Florida State |
| 95 | Denver | Keith McGill | Cornerback | Utah |
| 96 | Minnesota | Christian Jones | Linebacker | Florida State |
Fourth Round | Pick | Team | Player | Position | College |
| 97 | Houston | Ryan Carrethers | Defensive Tackle | Arkansas State |
| 98 | Washington | Donte Moncrief | Wide Receiver | Mississippi |
| 99 | Atlanta | Jeremy Hill | Running Back | LSU |
| 100 | Tampa Bay | Scott Crichton | Defensive End | Oregon State |
| 101 | Jacksonville | Marcus Roberson | Cornerback | Florida |
| 102 | Cleveland | D'Anthony Thomas | Running Back/WR | Oregon |
| 103 | Oakland | Billy Turner | Offensive Tackle | North Dakota St. |
| 104 | Minnesota | James Hurst | Offensive Tackle | North Carolina |
| 105 | Buffalo | Jack Mewhort | Offensive Tackle | Ohio State |
| 106 | St. Louis | Calvin Burnett | Defensive Tackle | Oklahoma State |
| 107 | Detroit | Weston Richburg | Center | Colorado State |
| 108 | Tennessee | Craig Loston | Safety | LSU |
| 109 | New York (G) | Chris Watt | Guard | Notre Dame |
| 110 | Dallas | Aaron Colvin | Cornerback | Oklahoma |
| 111 | New York (J) | Adrian Hubbard | Linebacker | Alabama |
| 112 | Miami | Devin Street | Wide Receiver | Pittsburgh |
| 113 | Chicago | Carl Bradford | Linebacker | Arizona State |
| 114 | Pittsburgh | A.J. McCarren | Quarterback | Alabama |
| 115 | Jacksonville | Jeff Janis | Wide Receiver | Sag Valley State |
| 116 | Arizona | Cameron Fleming | Offensive Tackle | Stanford |
| 117 | Green Bay | Josh Mauro | Defensive End/LB | Stanford |
| 118 | Philadelphia | Sean Parker | Safety | Washington |
| 119 | Cincinnati | Michael Sam | Defensive End | Missouri |
| 120 | Kansas City | Demarcus Lawrence | Defensive End | Boise State |
| 121 | San Diego | Andre Williams | Running Back | Boston College |
| 122 | New Orleans | Brett Smith | Quarterback | Wyoming |
| 123 | Cleveland | Ricardo Allen | Cornerback | Purdue |
| 124 | Carolina | Andrew Jackson | Linebacker | Western Kentucky |
| 125 | San Francisco | Aaron Lynch | Defensive End | South Florida |
| 126 | New England | Tyler Larsen | Center | Utah State |
| 127 | Denver | Kenny Ladler | Safety | Vanderbilt |
| 128 | Seattle | Joe Halapio | Guard | Florida |
Team-Team
Houston Texans: Jadeveon Clowney (DE), Johnny Manziel (QB), Ka'Deem Carey (RB), Ryan Carrethers (DT)
St. Louis Rams: Jake Matthews (OT), David Yankey (G), David Fales (QB), Yawin Smallwood (LB), Calvin Burnett (DT)
Jacksonville Jaguars: Tedd Bridgewater (QB), Kony Ealy (DE), Lache Seastrunk (RB), Marcus Roberson (CB), Jeff Janis (WR)
Cleveland Browns: Derek Carr (QB), Jason Verrett (CB), Brandin Cooks (WR), Ego Furgeson (DT), Marion Grice (RB), De'Anthony Thomas (RB/WR), Ricardo Allen (CB)
Oakland Raiders: Sammy Watkins (WR), Tre Mason (RB), Tajh Boyd (QB), Billy Turner (OT)
Atlanta Falcons: Khalil Mack (DE/LB), Troy Niklas (TE), Trevor Reilly (DE), Jeremy Hill (RB)
Tampa Bay Buccaneers: Ra'Shede Hageman (DT), Xavier Su'a-Filo (G), Scott Crichton (DE)
Minnesota Vikings: Blake Bortles (QB), Bradley Roby (CB), Paul Richardson (WR), Christian Jones (LB), James Hurst (OT)
Buffalo Bills: Eric Ebron (TE), Ryan Shazier (LB), Anthony Steen (G), Jack Mewhort (OT)
Detroit Lions: Mike Evans (WR), Cyrus Kouandjio (OT), Chris Borland (LB), Weston Richburg (C)
Tennessee Titans: Darqueze Dennard (CB), Charles Sims (RB), Craig Loston (S)
New York Giants: Greg Robinson (OT), Timmy Jernigan (DT), Brandon Coleman (WR), Chris Watt (G)
Chicago Bears: Aaron Donald (DT), Ed Reynolds (S), DaQuan Jones (DT), Carl Bradford (LB)
Pittsburgh Steelers: Zack Martin (OT), Kyle Van Noy (LB), A.J. McCarron (QB)
Dallas Cowboys: Ha'Sean Clinton-Dix (S), Gabe Jackson (G), Jimmy Garoppolo (QB), Aaron Colvin (CB)
Baltimore Ravens: Marqise Lee (WR), Antonio Richardson (OT), Carlos Hyde (RB)
New York Jets: Kelvin Benjamin (WR), Austin Seferian-Jenkins (TE), Loucheiz Purifoy (CB), Ahmad Dixon (S), Adrian Hubbard (LB)
Miami Dolphins: Cyril Richardson (OL), Morgan Moses (OT), E.J. Gaines (CB), Devin Street (WR)
Arizona Cardinals: Jace Amaro (TE), Zach Mettenberger (QB), Ed Stinson (DE), Cameron Fleming (OT)
Green Bay Packers: Calvin Pryor (S), Jeremiah Attaochu (LB), Daniel McCullers (DT), Josh Mauro (LB)
Philadelphia Eagles: Justin Gilbert (CB), Odell Beckham Jr. (WR), Terrence Brooks (S), Sean Parker (S)
Kansas City Chiefs: Jordan Matthews (WR), Colt Lyerla (TE), Demarcus Lawrence (DE)
Cincinnati Bengals: Lamarcus Joyner (CB), Shayne Skov (LB), Aaron Murray (QB), Michael Sam (DE)
San Diego Chargers: Anthony Barr (LB), Trent Muphhy (DE/LB), Jared Abbrederis (WR), Andre Williams (RB)
New Orleans Saints: Bishop Sankey (RB), Dee Ford (LB), Seantrel Henderson (OT), Brett Smith (QB)
Carolina Panthers: Allen Robinson (WR), Pierre Desir (CB), Ty Zimmerman (S), Andrew Jackson (LB)
New England Patriots: Luis Nix (DL), C.J. Fiedorowicz (TE), Josh Huff (WR), Tyler Larsen (C)
San Francisco 49ers: Davante Adams (WR), Deone Bucannon (S), Stanley Jean-Baptiste (CB), Dominique Easley (DT),
Bryan Stork (C), Aaron Lynch (DE)
Denver Broncos: Travis Swanson (C), Stephon Tuitt (DL), Keith McGill (CB), Kenny Ladler (S)
Seattle Seahawks: Will Sutton (DT), Jarvis Landry (WR), Joe Halapio (G)
Washington Redskins: Kyle Fuller (CB), Jimmy Ward (S), Donte Moncrief (WR)
Indianapolis Colts: Chris Smith (DE), Jackson Jeffcoat (LB)