Week 3 of the 2015 NFL season brings us a ton of interesting matchups, especially from a fantasy standpoint. As you prepare to set your lineups in year-long leagues and create new rosters in FanDuel and DraftKings contests, we are here to help. 

Here are your worst matchups for fantasy stars in Week 3 of the 2015 NFL season. 

Matthew Stafford, Quarterback, Detroit Lions (vs- Denver Broncos) 

Struggling through a rib injury, Stafford will likely start when the Lions make their home debut against the Denver Broncos on Sunday Night Football. And while we know the veteran quarterback performs at a much higher clip at home than on the road, this matchup is not friendly to his fantasy prospects for Week 3. 

Through two games, Denver has allowed a total of 5.82 fantasy points to opposing quarterbacks. During that very same span, its defense has yielded zero touchdowns compared to four interceptions. To put this into perspective, Denver corners are holding opposing signal callers to a 30.3 quarterback rating on the season. You can do the math from here. 

Sam Bradford, Quarterback, Philadelphia Eagles

At this point, Bradford could go up against pretty much any defense and it would work as a mismatch in the defense's favor. That's how bad the new Eagles quarterback hast been this season. Unfortunately for the Eagles, it won't get any easier against a stellar New York Jets defense on Sunday. 

The Jets, under first-year head coach Todd Bowles, have forced eight turnovers from the quarterback position and rank third in fantasy points against heading into Week 3. With a tough road crowd at The Meadowlands and an even more difficult Jets defense, Bradford is primed for another bad game. 

Matt Forte, Running Back, Chicago Bears

Forte may be the third-best fantasy running back through two weeks, averaging a total of 16.6 points per game, but he's going to be lucky to even hit half that mark against an angry Seattle Seahawks defense Sunday. Considering the Bears must travel to Seattle with Jimmy Clausen under center, any idea of the team being able to pass the ball successfully has to be thrown out the window. This means that Seattle will stack the box. Enter into the equation the return of Kam Chancellor from an extended holdout, and this is magnified further. 

Not to be too negative here, Forte will also be tasked with going up against a Seahawks defense that ranked second in the NFL against fantasy running backs last season and is fourth in that category this year. In fact, the Seahawks are yielding an average of 3.7 yards per rushing to running backs through two games. 

DeMarco Murray, Running Back, Philadelphia Eagles

This is assuming for a second that the MRI on Murray's injured hamstring provides the Eagles with the first good news they have received all season. If this struggling running back is able to go against the Jets, he's nothing more than a ride the pine fantasy option. Not only has Murray put up a total of 11 yards on 21 rush attempts (that's a real stat) this season, he's slated to run against a New York Jets defense that is yielding an average of 2.9 yards per rush to opposing running backs this season.

We don't need to be geniuses to realize what the end result is likely going to be here. Even if you drafted Murray high during the summer, you have to seriously consider benching him this week. That's the harsh reality of the situation. 

Calvin Johnson, Wide Receiver, Detroit Lions

I could just tell you to read the Matthew Stafford blurb and leave it there. Maybe I just like to hear myself write, but there's more to it here. Johnson will line up against a corner in Aqib Talib who might be the best player at his position in the NFL right now. Talib has allowed three receptions and picked off two passes in two games thus far this year. Overall, opposing quarterbacks have a 5.1 rating against him during that span. 

For his part, Johnson hasn't been incredibly successful through two games. While he is catching 60 percent of the passes thrown in his direction, he's averaging just 5.6 yards per target. Going up against Talib, Megatron has his hands full. 

Keenan Allen, Wide Receiver, San Diego Chargers

Allen followed up a ridiculous 15-catch performance against Detroit in Week 1 by putting up just two catches against Cincinnati this past weekend. Outside of the inconsistency he's shown this year, the third-year wide receiver will be tasked with attempting to beat a corner in Xavier Rhodes who has proven himself to be among the best young shut down guys in the NFL. 

Through two games, Rhodes is averaging about five yards per targeted pass thrown in his direction. He's also allowing quarterbacks to complete just over 50 percent of their throws in his direction. Look for similar numbers come Sunday. 

Tyler Eifert, Tight End, Cincinnati Bengals

This might in fact be the week to avoid Eifert in DFS or standard leagues. Despite ownership of opposing defenses through two games (three touchdowns), Eifert will be forced to beat the likes of C.J. Mosley and Will Hill in the passing game. And considering the Ravens have yielded a total of 3.0 fantasy points to tight ends this year, it's hard to imagine Eifert eating big time here. Heck, Baltimore is giving up an average of less than three yards per targeted pass to tight ends.