1. Peyton Manning, Denver Broncos (KC)

Without Derrick Johnson, the Chiefs’ pass rush will be significantly hobbled for the remainder of the season. Manning’s receivers had some problems with drops Sunday night against the Indianapolis Colts, but he and Julius Thomas picked up right where they left off last season, connecting on three touchdowns. There’s no reason to believe that Manning won’t go for three more against Kansas City.

Projected Statistics: 400 yards, three touchdowns, no interceptions

2. Aaron Rodgers, Green Bay Packers (NYJ)

Rodgers is certainly no Derek Carr. New York’s pass rush bothered the rookie quarterback on Sunday, but Rodgers and Green Bay’s offensive line will be able to handle that much better than the Raiders. New York’s secondary is hurting still, and Carr was able to throw two touchdowns in Week 1. Don’t let a game against the Seahawks worry you, Rodgers will return to form this week.

Projected Statistics: 340 yards, two touchdowns, one interception

3. Drew Brees, New Orleans Saints (CLE)

Brees only managed one touchdown against the Atlanta Falcons in Week 1 and threw an interception, but the Cleveland secondary may not be as good as we once thought. Justin Gilbert is having a tough time adjusting to the NFL, and Antonio Brown was able to exploit Joe Haden on Sunday in the first half. Plus, Brees is still Brees and Brandin Cooks looks to be ready to put up big numbers on his own.

Projected Statistics: 340 yards, two touchdowns, two interceptions

4. Andrew Luck, Indianapolis Colts (PHI)

Philadelphia’s secondary made Allen Hurns a household name for a few hours, and Luck had 370 yards, two touchdowns and two interceptions against Aqib Talib and the Denver secondary. He’s developing quite the chemistry with Reggie Wayne once again now that Wayne’s healthy, and Dwayne Allen seems to be a reliable red zone target. A complete lack of a rushing game from Trent Richardson could hurt Luck in the long-run, but this matchup should yield at least 20 fantasy points.

Projected Statistics: 310 yards, two touchdowns, one interception

5. Matthew Stafford, Detroit Lions (CAR)

Note: At the time of writing, the Monday night game had not been played.

Carolina’s defense sounds like a tough matchup on paper, but Stafford will be fine with the weapons at his disposal. Eric Ebron, Calvin Johnson and Golden Tate are all very talented, and as long as he can make better decisions with the football and not turn the ball over, his weapons will do the work for him.

Projected Statistics: 280 yards, two touchdowns, no interceptions

6. Tom Brady, New England Patriots (MIN)

As Rob Gronkowski goes, Brady goes. With Gronk in the lineup, Brady had a touchdown and 249 yards against the Miami Dolphins, with the touchdown going to his favorite tight end. Minnesota’s defense was overhauled in the offseason, but it’s tough to really judge them against two different St. Louis Rams quarterbacks. If any receiver besides Julian Edelman will step up for Brady, he’s a threat to break the top five.

Projected Statistics: 260 yards, two touchdowns, no interceptions

7. Matt Ryan, Atlanta Falcons (CIN)

With Roddy White and Julio Jones healthy, Ryan caught fire in Week 1, throwing for almost 450 yards and three touchdowns. If there’s a weakness on Cincinnati’s roster, it’s the secondary, and while Ryan likely won’t produce the same numbers this week, he will be a must-start in all leagues.

Projected Statistics: 250 yards, two touchdowns, one interception

8. Colin Kaepernick, San Francisco 49ers (CHI)

Kapernick had a solid game in Week 1 against the Dallas Cowboys, but it wasn’t great. He had just 11 rushing yards and barely broke 200 yards even with the receiving threats at his disposal, but Vernon Davis seems to be in top form, and the Bears defense is struggling again after allowing E.J. Manuel and Buffalo’s running game to take over a game. Unless the 49ers have made a major change in their playcalling attitudes, Kaepernick should do more in the running game this week.

Projected Statistics: 210 yards, one touchdown, five carries, 40 rushing yards

9. Cam Newton, Carolina Panthers (DET)

Assuming Newton is completely healthy now, he will produce against a sub-par Lions secondary. After taking a lot of heat in the pre-draft process for his hands, Kelvin Benjamin showed in his NFL debut, catching six passes on eight targets, one of them for a touchdown. As everyone knows, Newton will also gain some value for what he can do on the ground. As long as he’s healthy, he’s an easy play as a top 10 quarterback.

Projected Statistics: 170 yards, one touchdown, two carries, 10 yards, one rushing touchdown

10. Andy Dalton, Cincinnati Bengals (ATL)

Heading into drafts, Dalton was slept on for being a quarterback who turns the ball over too much for fantasy purposes, but he broke 300 yards against the Baltimore Ravens and didn’t throw a single interception. Having A.J. Green obviously helps, but so does the two-headed monster of Giovani Bernard and Jeremy Hill in the backfield. Dalton will continue to surprise people this season who continue to bench him in fantasy.

Projected Statistics: 230 yards, two touchdowns, two interceptions