| Rank: | Name: | Opponent: | Note: |
| 1. | Tom Brady | v. MIA | Brady and Patriots' offense is rolling, now face MIA defense allowing sixth-most passing TDs per game in last four weeks. |
| 2. | Russell Wilson | @ SF | 49ers' defense allows ninth-most passing yards per game this season and seventh-most passing TDs per game in last month. |
| 3. | Ben Roethlisberger | v. GB | Big Ben holds a 24-3 TD-INT ratio in his last seven primetime games. SNF matchup against a bad Packers' secondary. |
| 4. | Cam Newton | @ NYJ | With 40-plus rushing yards in each of his past two games, the old Cam is back and a great matchup makes him an extreme upside play. |
| 5. | Carson Wentz | v. CHI | Bears' defense allowed 10th-most passing yards per game in last month, will struggle against numerous Eagles' weapons. |
| 6. | Marcus Mariota | @ IND | 10 days to prepare for a Colts' secondary that allows third-most pass yards per game (275) and highest yards per attempts (8.3) |
| 7. | Kirk Cousins | v. NYG | NYG secondary allows seventh-highest QB Rating (96.6) and fourth-most passing touchdowns (20) makes for a great matchup. |
| 8. | Matt Ryan | v. TB | Ryan faces Buccaneers' secondary that allows second-most pass yards per game (276) and fifth-highest completion percentage (66.7). |
| 9. | Drew Brees | @ LAR | Brees' matchup against Rams' defense that allowed just over 240 pass yards per game on 37 attempts will be tough, but weapons around him give him chance to put up quality numbers. |
| 10. | Alex Smith | v. BUF | Delivered an ugly performance against New York, but should bounce back against Bills' secondary that allowed 921 passing yards in last four games. |
| 11. | Jared Goff | v. NO | If New Orleans is without its top cornerback Marshon Lattimore, Goff becomes a top-10 play. |
| 12. | Andy Dalton | v. CLE | Cleveland allows fourth-highest completion percentage in NFL and third-highest QB Rating (102.3). Pass rush will test the Bengals, but Dalton should finish the week as top-12 play. |
| 13. | Case Keenum | @ DET | A risky call but Lions allowed fifth-most passing yards (978) in the past four weeks and Keenum is surrounded by weapons that make him worth this spot. |
| 14. | Matthew Stafford | v. MIN | Vikings' defense allowed just one passing touchdown and 731 total passing yards in its past three games. Stafford is on a streak, but the matchup is tough. |
| 15. | Dak Prescott | v. SD | If left tackle Tyron Smith is out, Prescott slides out of the top 15 against San Diego's front seven. |
| 16. | Philip Rivers | @ DAL | Cowboys have allowed under 230 passing yards per game in their past four contests. Meanwhile, Rivers hasn't surpassed 280 passing yards since Oct. 1 |
| 17. | Joe Flacco | v. HOU | Texans' defense allowed second-most passing yards in the past four weeks (1,372) and nearly 300 yards more than the third-worst defense (1,044). |
| 18. | Tyrod Taylor | @ KC | While Chiefs' defense allowed fourth-fewest passing yards in the last month (652), Taylor's rushing ability adds to his fantasy floor. Of course, this all depends on Buffalo starting the right quarterback. |
| 19. | Jacoby Brissett | v. TEN | Must clear the concussion protocol, but matchup is there to take advantage of if he does. TEN allowed eighth-most pass yards per game in last four weeks. |
| 20. | Jimmy Garoppolo | v. SEA | A secondary without Richard Sherman and Kam Chancellor paired with an absent pass rush, takes the teeth out of this defense. Jimmy G is a quality DFS play if he makes 49ers' debut. |
| 21. | Eli Manning | @ WAS | If Sterling Shepard can return in Week 12, a matchup against an injury-depleted Washington' secondary that allows fifth-most passing yards per game (279), Manning is a DFS cash game play. |
| 22. | Derek Carr | v. DEN | Just look back at his 143-yard, one touchdown performance the last time he faced Denver. Find other options in DFS and season-long leagues. |
| 23. | Ryan Fitzpatrick | @ ATL | With Jameis Winston ruled out for another week, Fitzpatrick will have plenty of opportunities to throw deep as the Buccaneers try to play catchup. |
| 24. | Blake Bortles | @ ARZ | Jaguars' defense should provide Bortles with some short-field opportunities. In a bad matchup, Bortles could post a touchdown and 200 yards. |
| 25. | Matt Moore | @ NE | The better of Miami's quarterbacks, Moore should start if Jay Cutler remains in concussion protocol. Patriots' defense is greatly improving, but could ceded fantasy points with a big lead. |