NFL Preview of Arizona Cardinals vs San Francisco 49ers on September 21st 2025

Season:

Week:

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

Final

Odds

	Spread	MoneylineMoney	Total
San Francisco 49ers49ers	-1 ¹⁄₂ -115	400	44.00 o -110u -110
Arizona CardinalsCardinals	+1 ¹⁄₂ -105	-599	44.00 o -110u -110
Spread Consensus: San Francisco 49ers: 0% Arizona Cardinals: 0%
Vegas Prediction: San Francisco: 23 (Win) Arizona: 21 (Loss)

Season Series

Jan 5^th 2025 San Francisco 24 @ Arizona 47

Oct 6^th 2024 Arizona 24 @ San Francisco 23

Dec 17^th 2023 San Francisco 45 @ Arizona 29

Oct 1^st 2023 Arizona 16 @ San Francisco 35

San Francisco	Stats	Arizona
2-2	Vs	2-2
127	Points	116
15	Touchdowns	13
5/6	Field Goals	9/10
86/127 (1062 yd.)	Passing	98/145 (890 yd.)
111 CAR (559 yd.)	Rushing	108 CAR (659 yd.)

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